Question: Where is acetyl choline manufactured?

Jacquie Oliwa answered on 10 Jul 2017:

Hi Dynaset,
Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals, including humans, as a neurotransmitter—a chemical released by nerve cells to send signals to other cell. It is synthesized within the nerve terminals from choline, taken up from the tissue fluid into the nerve ending by a specialized transport mechanism.

The enzyme necessary for this synthesis (choline acetyltransferase) is formed in the nerve cell body and passes down the axon to its end, carried in the axoplasmic flow, the slow movement of intracellular substance (cytoplasm). Acetylcholine is stored in the nerve terminal, sequestered in small vesicles awaiting release from nerve endings (terminals) in both the peripheral and the central nervous systems when an action potential reaches the nerve terminal.

Best wishes,
Jacquie